LGLs represent a complex spectrum of different clinico- pathological entities, ranging from benign reactive lymphocytosis to overt malignant leukaemia. Although patients with mycosis fungoides (MF) are known to be at increased risk of additional haematological neoplasms

Journal Compilation © 2012 Acta Dermato-Venereologica. ISSN 0001-5555 Large granular lymphocytes (LGLs) are medium-to-large cells, of either Tor natural killer (NK)-cell lineage, characterized by eccentric nuclei, condensed chromatin, and abundant pale cytoplasm containing coarse azurophilic granules (1, 2). Proliferative conditions of Tand NKLGLs represent a complex spectrum of different clinicopathological entities, ranging from benign reactive lymphocytosis to overt malignant leukaemia. Although patients with mycosis fungoides (MF) are known to be at increased risk of additional haematological neoplasms (occurring either before or following the appearance of MF lesions) (3, 4), no association with LGL proliferative disorders has been described. We report here a patient who developed MF in the setting of T-LGL proliferative disorder, and discuss the possible pathogenetic implications of this previously unreported association.